LMP301H1 - Introduction to the Biochemistry of Human Disease

Not intended for students in the Pathobiology Specialist program.

Course description

This course introduces concepts and mechanisms of disease processes as they arise from disturbances of normal biochemical and physiological functions.

The rational use of the clinical biochemistry laboratory in the diagnosis and management of disease is explained.

Course coordinator

Dr. Lianna Kyriakopoulou

Hospital for Sick Children, 555 University Ave., Room S102 Elm Wing

lianna.kyriakopoulou@sickkids.ca

Dr. Lei Fu

Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, 2075 Bayview Avenue

Lei.Fu@sunnybrook.ca

Teaching assistant

Justin Meade

justin.meade@mail.utoronto.ca

Term	Winter 2024
Class time	Tuesday and Thursday 12 - 1 pm
Class and office hours location	Please see ACORN for location.
Office hours	Thursday February 1, Thursday March 7, and Thursday April 4 - 1 - 2 pm

Course details

Hours: 24L
Prerequisite: BCH210H1/ BCH242Y1
Exclusions: LMP340H1 / LMP350H1
Distribution requirements: Science
Breadth requirement: Living Things and Their Environment (4)
Enrolment limits: 210 students

Student evaluation

In-class mid-term 1: 25%

In-class mid-term 2: 25%

Final exam: 50%

See information on Academic Integrity

Schedule

Date	Title	Instructor
January 9, 2024	Introduction to human disease	Dr. Lianna Kyriakopoulou
January 11, 2024	Laboratory tests and interpretation	Dr. Lianna Kyriakopoulou
January 16, 2024	Introduction to cases	Dr. Lianna Kyriakopoulou
January 18, 2024	Water and electrolytes	Dr. Rajeevan Selvaratnam
January 23, 2024	Acid-Base disorders	Dr. Rajeevan Selvaratnam
January 25, 2024	Renal disease	Dr. Rajeevan Selvaratnam
January 30, 2024	Lipids and cardiac disease	Dr. Rajeevan Selvaratnam
February 1, 2024	Liver Disease Office Hour	Dr. Lianna Kyriakopoulou
February 6, 2024	Viral hepatitis	Dr. Lianna Kyriakopoulou
February 8, 2024	First Mid-term Exam (Covers Lectures 1-7)
February 13, 2024	Introduction to endocrine diseases	Dr. Benjamin Jung
February 15, 2024	Thyroid disease Supplemental Exam	Dr. Lianna Kyriakopoulou
February 19, 2024	Reading Week
February 27, 2024	Adrenal disease	Dr. Benjamin Jung
February 29, 2024	Calcium, Vitamin D and Parathyroid	Dr. Benjamin Jung
March 5, 2024	Infertility	Dr. Lianna Kyriakopoulou
March 7, 2024	Diabetes Office Hour	Dr. Lianna Kyriakopoulou
March 12, 2024	Iron and heme	Dr. Lianna Kyriakopoulou
March 14, 2024	Cancer markers	Dr. Lianna Kyriakopoulou
March 19, 2024	Second Mid-term Exam (covers lectures 8 - 15)
March 21, 2024	Newborn screening	Dr. Lianna Kyriakopoulou
March 26, 2024	Pregnancy	Dr. Lei Fu
March 28, 2024	Clinical toxicology Supplemental Exam	Dr. Lei Fu
April 2, 2024	Therapeutic drug monitoring & Personalized medicine	Dr. Lei Fu
April 4, 2024	Molecular diagnostics Office Hour	Dr. Lei Fu
TBC	Final Exam (covers lectures 1-22)