LMP1108H: Genome analysis in medicine

Who can attend

There are no prerequisites for this course.

Course description

The advent of next-generation sequencing technologies coupled with decreasing cost has accelerated the pace of gene discovery and revolutionized DNA based diagnostics.

You will become familiar with current methods in the analysis and medical interpretation of genomic sequence data.

By the end of this course you will understand how to:

  • analyze a genome
  • interpret a genome

You will follow the steps of genomic analysis and complete assignments each week that use the resources we discuss in lectures.

You will complete a term project to analyze a raw genome sequence and report on the relevant findings.

Course coordinators

Dr. Christian Marshall
crm@sickkids.ca

Dr. Michelle Axford
michelle.axford@sickkids.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every year in the Winter session.

Tuesdays 1 pm – 4 pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Weekly assignments - 50%

Term project - 25%

Final exam - 25%

Schedule

date topic lecturer/instructor
March 2, 2021 Genome Structure and Variation Dr. Michelle Axford
March 9, 2021 Genome Sequencing Methodologies Dr. Christian Marshall
March 16, 2021 Informatics Approaches to Genomic Analysis Dr. Christian Marshall
March 23, 2021 Genome Annotation and Interpretation Dr. Michelle Axford
March 30, 2021 Medical and Diagnostic Applications of Genome Analysis Dr. Christian Marshall
April 6, 2021 Term Project and Exam

Dr. Michelle Axford

Dr. Christian Marshall