LMP1207H: Mass spectrometry, proteomics and their clinical applications

Who can attend

You must be registered in a graduate program to attend this course.

This course is open to all graduate students at the University of Toronto, provided you have pre-approval from your department and the course coordinators.

Course description

You will learn the fundamentals of mass spectrometry and its use with biochemical techniques to provide analyses of proteins and small molecules.

You will also study the interface with bioinformatics and other -omics technologies.

The second half of the course is designed to bridge the gap between basic and translational sciences and will examine the research and clinical applications of mass spectrometry.

Course coordinators

Dr. Vathany Kulasingam
vathany.kulasingam@uhn.ca

Dr. Lusia Sepiashvili
lusia.sepiashvili@sickkids.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every even year in the Fall term (i.e. 2020, 2022 etc).

Wednesdays 10 am – 12 pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Two written examinations:

  • Mid-term - 30%
  • Final exam - 30%

Presentation of a journal article - 20%

Take-home assignment - 20%

Schedule

date topic lecturer/instructor
September 9, 2020 Introduction to mass spectrometry and proteomics Dr. Vathany Kulasingam
September 16, 2020 Basic principles of mass spectrometry Dr. Andrea Bozovic
September 23, 2020 Fundamentals of proteomics Dr. Lusia Sepiashvili
September 30, 2020 Bioinformatics: Protein Identification and Targeted Proteomics Dr. Vathany Kulasingam
October 7, 2020 Integration of proteomics with other -omics technologies TBC
October 14, 2020 Mid-term exam  
October 21, 2020 Post-translational modifications and Protein-protein interactions TBC
October 28, 2020 Analytical workflows for sub-proteome analyses Dr. Lusia Sepiashvili
November 4, 2020 Clinical microbiology and toxicology

Dr. Susan Poutanen

Dr. Stefan

November 11, 2020 Mass Spectrometry Imaging

Dr. Zarrine-Afsar

Medical Biophysics

November 18, 2020 Mass spectrometry for metabolic and molecular genetics Dr. Lianna Kyriakopoulou
November 25, 2020 Emerging applications of Proteomics and MS

Dr. Vathany Kulasingam

Dr. Lusia Sepiashvili

December 2, 2020 Final examinations