LMP1105: Current understanding of Atherosclerosis

Who can attend

There are no prerequisites for this course.

Course description

We will critically explore, in depth, Atherosclerosis, a major cardiovascular disease.

Each week, we will identify, present and discuss gaps in knowledge in understanding the pathogenesis of atherosclerosis.

You will present recent high-quality peer reviewed original research papers on the cell and molecular pathogenesis of atherosclerosis and relate these papers to current literature.

You are expected to read all the assigned reviews and original research papers prior to the seminar in order to participate and contribute meaningfully to the seminar discussions.

Your presentation will focus on cell and molecular biology, discovery sciences and translational research in cardiovascular disease. Following your presentation, the class will discuss.

The format of each two-hour weekly seminar is:

  • a brief introduction by the instructor
  • assigned student presentations on the topic of the day
  • full class discussion.

Course coordinator

Dr. Avrum I. Gotlieb
avrum.gotlieb@utoronto.ca

lmp.grad@utoronto.ca for administrative queries.

Timings and location

This course is offered every year in the Fall session.

Fridays 10 am – 12 pm

Location: Synchronous online delivery (Zoom)

Evaluation methods

Journal presentations - 30%: A review and an original research paper

Participation in seminar discussions - 20%. You are expected to attend all seminars.

Final Report - total 50% (10% abstract presentation, 40% final written report)

You will be assigned a topic in the first week of the course by the instructor.

You will write an original six-page report (excluding reference, tables, and figures) on the major gaps in knowledge on your specific topic in atherosclerosis research. Your report will include a comprehensive background literature review to identify these gaps.

You should discuss the rationale for choosing these gaps and include an in-depth discussion describing these gaps.

Finally, you should discuss innovative research strategies in cell/molecular biology that can be designed and carried out to fill these gaps in knowledge. This should deal primarily with utilizing novel ideas to design experimental approaches to discover new useful knowledge to understand pathogenesis of atherosclerosis.

You should use high quality, up-to-date references to develop your report.

You will present an Abstract of the report to the class (oral and written) on week six and submit the final report one week later.

Schedule

All sessions are led by Dr. Avrum I. Gotlieb.

Lecture - Dates TBC Topic
Lecture 1 Introduction to plaque morphology, contents, and complications
Lecture 2 Approaches to the study of Atherosclerosis; human, animal, and in vitro models (student presentations)
Lecture 3 Interactions at blood – vessel wall interface (student presentations)
Lecture 4 Pathogenesis; Intima-Media Compartment (student presentations)
Lecture 5 Pathogenesis; Adventitia-PVAT Compartment (student presentations)
Lecture 6 Final Report Abstract Presentations (students)