The Adeli Lab’s basic research program aims to elucidate the cellular, molecular, and physiological regulation and hepatic lipoprotein production in normal and insulin-resistant states. In recent years, the incidence of insulin-resistant states such as obesity and type 2 diabetes have been increasing at an alarming in both pediatric and adult populations. These conditions represent major risk factors for atherosclerotic cardiovascular disease, largely due to lipid and lipoprotein abnormalities. The key mechanism underlying this metabolic dyslipidemia is hepatic and intestinal overproduction of atherogenic lipoproteins. Currently, the laboratory is investigating the neuroendocrine mechanisms regulating intestinal and hepatic lipoprotein overproduction in insulin-resistant states and the role of the gut-brain-liver axis in lipid and lipoprotein metabolism
Aside from basic research, the Adeli Lab also conducts various clinical research projects. This includes the CALIPER (Canadian Laboratory Initiative on Pediatric Reference Intervals) program, which aims to establish a comprehensive database of reference or “normal” ranges for medical laboratory tests in children and adolescents. The CALIPER database, which now contains reference intervals for hundreds of laboratory biomarkers, is used by thousands of institutions across Canada and around the world to improve clinical assessment, diagnosis, and monitoring of children with medical concerns.
For more information on the basic and clinical research programs, please visit the Adeli Lab website.