LMP406H1 - Pathobiology of the Cardiovascular System 24L
You will learn about, with emphasis is on the underlying cell biology, the following processes:
- Pathobiology of the heart and blood vessels.
- Congenital and acquired diseases of the vasculature.
- Treatments of vascular disease and cardiovascular biomaterials.
- Major focus on atherosclerosis and hypertension.
By the end of this course, you should be able to complete the following:
- Describe the pathogenesis of vascular diseases including atherosclerosis and hypertension
- Discuss mechanisms and signaling cascades that facilitate disease development/progression
- Compare and contrast advantages and limitations of experimental models in CV research
- Design experiments to test the potential effects of protein X malfunction in the CV system
Quercus (UTORID needed)
You will access all course materials and submit all work via Quercus for this course.
We will use this platform to make all announcements and communications to you.
Please email the course instructor or TA directly when you need them.
University Health Network (UHN): Toronto General Hospital
|Class location and time||
Tuesday 10:00 am-12:00 pm
Online Synchronous (Bb Collaborate)
Tuesdays 1-3 pm via Zoom.
Please email to meet outside of these hours.
- Hours: 24 L
- Prerequisites: PSL300H1, PSL301H1 or PSL302Y1
- Exclusions: None
- Distribution Requirements: Science
- Breadth Requirement: Living Things and Their Environment (4)
- Enrollment limit: Yes – 30 students
- Required Readings: None, only lecture notes/slides
Mid-term Assessment: 30% Due date: February 9 (in class)
Article Review Assignment: 15% Due date: March 23 (11:59pm)
Final Assessment: 55% Due date to be announced
Midterm and final assessments
Assessments are not cumulative.
The midterm will cover all lectures prior to February 9 and will be during class hours.
The Final assessment will cover lectures from Feb 23 to the end of term. The final assessment is scheduled through the university and will occur during the end of term period.
The format will be short answer questions. Each guest lecturer will submit and mark their own questions. Study materials include all lecture slides.
Article Review Assignment
Each student will be assigned a primary research article to prepare a written review on during the first week of class.
Each article will be selected by the course lecturers and be relevant to a topic discussed in the course. Each review assignment will consist of a summary of the major findings, impact of study, limitations and proposal of 1-2 additional experiments to validate or build upon the research claims.
Detailed word limits, guidelines, and rubric will be available on Quercus during the first week of class.
All submissions will be uploaded electronically to Quercus by 11:59pm. Late submissions are subjected to a 3% penalty per day (including weekends) up to five days (15%).
Lectures and recordings
All lectures will be delivered synchronously online. Students are expected to attend sessions, however, all lectures will be recorded and available for the entirety of the course.
Lectures and content are the intellectual property of the lecturer and should not be used without permission.
|January 12||Introduction to the cardiovascular system and atherosclerosis||Amanda Mohabeer|
|January 19||microRNA regulation in atherosclerosis||Kathryn Howe|
|January 26||Hypertension||Scott Heximer|
|February 2||Cardiovascular Regeneration||Sara Vasconcelos|
|February 9||Midterm assessment (in class)|
|February 16||Reading week|
|February 23||Circadian rhythms and microvascular function||Jeffery Kroetsch|
|March 2||Inflammatory Mechanisms||Myron Cybulsky|
|March 9||Pulmonary Hypertension||Quinn Bonafiglia|
|March 16||Vascular Development||Paul Delgado|
|March 23||Vascular Malformations||Jason Fish|
|March 30||Arterial Stiffening||Amanda Mohabeer|
|April 6||Aneurysms, experimental models, and case studies||Amanda Mohabeer|