Metabolism & Nutrition
Metabolism & Nutrition encompasses the molecular basis of biological processes as they relate to endocrine, reproductive, metabolic and nutritional disorders. Our researchers study the mechanisms in diabetes, endocrine function and dyslipidemias. Others are investigating the role of nutrients and of toxic substances such as metals in our environment. The effects of hormones on tissues such as the thyroid, bone, and reproductive organs are also included in this area of research. Experimental approaches include investigations of gene structure and function, cell signaling, transcriptional regulation, metabolomics, mouse genetics and animal physiology.
Faculty members are involved in innovative clinical and basic research that focuses on:
- the pathogenesis of obesity and Type II diabetes
- identification of autoimmune markers and mediators of Type I diabetes
- pancreatic stem cells and islet transplantation
- metabolic disorders of blood lipids that lead to hypercholesterolemia and dyslipidemia
- insight into metabolic factors that contribute to bone loss, osteoporosis and renal failure
- endocrine derangements that accompany conditions of the thyroid, pituitary and reproductive glands
Faculty Involved in Metabolism & Nutrition Research
Molecular and cellular biology of lipoprotein metabolism in insulin-resistant states such as obesity and diabetes, and the link with cardiovascular disease.
Main fields in which I collaborate with researchers, clinicians, biotech or Pharmaceutical companies: Evaluation of biomarkers and clinical validation all the way to regulatory submissions (FDA, Health Canada), development and optimization of biomarkers/assays, handling clinical trials (development of assays, project management,…), validation of medical devices, and any process or assays towards personalized medicine.
My research interest focuses on pharmacokinetics and therapeutic drug monitoring/toxicology with application towards investigating the expression of drugs into breast milk and the risk these drugs may pose to the nursing infant.
Our research interests include a wide range of genetic conditions, but our laboratory has a specific focus on genetic and non-genetic contributions to disordered bone and mineral metabolism.
Biomarker investigation in subjects with or at risk for diabetes and renal disease. Basic mechanisms of the lactonase, paraoxonase 1 in atherosclerosis and inflammation.
Research in the Drucker lab is focused on understanding the biology of the glucagon-like peptides. Specific projects include physiological analyses of GLP-1 and GLP-2 action, understanding the biology of glucagon action, and elucidation of the functional control of GLP-1, GIP, and GLP-2 action through studies of their respective receptors.
Using a range of molecular, cell biology, animal and clinical approaches my laboratory conducts research into the pathogenesis of diabetes complications with the overriding aim of developing new therapies to prevent and treat them.
Dr. Grynpas laboratory research is focused on: the nature of bone mineral, animal models of osteoporosis and osteoarthritis, the effects of drugs and trace elements on bone quality, the determinants of bone fragility and bone fatigue. He is also part of a research group investigating tissue engineering of skeletal tissues.
Our research interests are in the origin and evolution of new gene function focusing on genes that are involved in Diabetes.
My research focuses on genetic metabolic disorders. Currently, the emphasis is on understanding the pathobiology of Congenital Disorders of Glycosylation as well as developing new methods for the diagnosis of this group of diseases.
Our laboratory studies the functional role of glycosphingolipids in cell physiology and disease pathology. Abnormal GSL metabolism is associated with many human diseases and major aspects of their metabolism remain undefined.
To investigate the mechanistic role of cellular cholestero and lipidsl in the development of diabetes, non-alcoholic fatty liver disease and cardiovascular diseases using transgenic mouse models
Our research program focuses on molecular networks implicated in cancer and diabetes. We are investigating signaling pathways contributing to tumor initiation, cancer stem cell maintenance and metastatic dissemination of breast cancers. We are also exploring mechanisms governing insulin resistance and pancreatic β-cell replication important for the design of regenerative therapies for type 1 and type 2 diabetes.
Our research activities focus on discovering novel methods to prevent and treat intestinal injury in humans and enhance the quality-of-life and health of Canadians.
Our group is investigating adipose tissue biology - how does adipose tissue grow (fat expansion) and what is the origin of adipocyte (adipocyte precursor cell) by using multiple transgenic mouse model system.
Metallic elements play essential roles in normal cell function as enzyme cofactors, redox sensors, and structural elements. They also include some of the most potent toxic substances in our environment. We study the cell biology and toxicology of metals, with a current focus on iron and cadmium.
My main interest is in Therapeutic Drug Monitoring (TDM) and Clinical Toxicology. Also interested in Genetic Metabolic Disease, (small molecule disease). Interested in detection of drugs in overdose cases by chromatographic and immunoassay methods for clinical applications. Quantitation of Immunosuppressives in blood for TDM. Development and evaluation of new methods for drug analysis.
Dr. Wong's research interest is in immunodiagnostics, biomarker discovery and metabolism of immunosuppressants.
My lab is interested in understanding novel mechanisms of fibrovascular injury in the kidney, using both cell and animal models of disease, with the goal of using the knowledge gained to develop innovative new therapies for kidney disease.