Platelet (green) adhesion and aggregation, fibrin (red) formation, and their interaction (yellow) at the site of laser-induced, cremaster vessel injury observed under intravital microscopy.
Platelet (green) adhesion and aggregation, fibrin (red) formation, and their interaction (yellow) at the site of laser-induced, cremaster vessel injury observed under intravital microscopy.
Courtesy of H. Ni

Hematopathology

Researchers of hematopathology study diseases of hematopoietic cells which originate from the bone marrow and contribute to the cellular components of blood. These components include red blood cells, white blood cells, and platelets. Researchers also investigate the nature of disease of the hematopoietic system and related organs, including the bone marrow, spleen, thymus, lymph node and vasculature. As such, diseases of this system are myriad and include hereditary and congenital disorders, as well as acquired disorders. Complicating matters further, hematopathology disorders may be immunological in nature as well. It is not surprising that researchers involved in hematopathology possess a diverse expertise critical to the study of, but not limited to, transfusions and transplants, drug delivery, immunity, cancer, and blood clots. This expertise also extends to our understanding of strokes and heart attacks which are the leading cause of morbidity and mortality worldwide.

Our researchers focus on various aspects of hematopathology, including:

  • platelets and blood coagulation system in bleeding disorders and cardiovascular diseases
  • the role of the immune system in hematological disease
  • molecular and cellular aspects of hematopoiesis
  • myelodysplastic syndromes
  • diagnostic research

Faculty Involved in Hematopathology Research

Associate Professor

Dr. Branch’s research includes:  (1) Investigation of the pathogenesis of HIV to identify new host cell targets for alternative therapies. (2) Projects related to the mechanism of action and replacement of intravenous immunoglobulin (IVIG). (3) The role of the signalling molecules SHP-1 and  c-Src  in cancers and HIV infection.   

Associate Professor
Jeannie Callum
Associate Professor

My current research areas of focus are in the following areas: (1) Transfusion support in trauma patients; (2) Transfusion support following cardiac surgery; (3) Transfusion triggers in critically ill patients; (4) Adverse reactions to blood products; (5) Transfusion-related process errors; and, (6) Management of peri-pregnancy and perioperative iron deficiency anemia.

Professor

We are interested in studying the molecular pathogenesis of multiple myeloma (MM) and identifying prognostic and predictive biomarkers in MM. We are also interested in pre-clinical evaluation of small molecules targeting various oncogenic signaling pathways as novel therapeutic strategies in MM.      

Assistant Professor

Research and education focus on transfusion medicine and benign hematology (ie- adverse reactions to blood products; immunologic hematopathologies in autoimmune disease, transfusion, or transplantation; and adaptive/evolutionary blood group biology).

Professor

Lymphoma research interests
1. diagnostics, biology and immunology of lymphoma.
2. pathology review for trials 

Lecturer

Areas of special interest/expertise: Medical Laboratory Management, Bone Marrow and Peripheral Blood Morphology, Flow Cytometry and Hemoglobinopathies.

Assistant Professor
Assistant Professor

Dr. Ghaffar is an Assistant Professor in Laboratory Medicine and Pathobiology at the University of Toronto, Adjunct Scientist in the Keenan Research Centre of the Li Ka Shing Knowledge Institute and  Director of Laboratory Hematology at St. Michael's Hospital.  His main areas of interest include lymphoproliferative disorders and flow cytometry.

Assistant Professor

Primary research interests include: (1) the application of molecular techniques to assist in the diagnosis and prognosis of solid and hematologic tumours; (2) understanding the genetic and epigenetic landscape of leukemias and lymphomas to determine its impact on disease pathogenesis.   

Assistant Professor
Lecturer
Assistant Professor
Professor

Understanding how therapeutic antibodies can be used to treat autoimmune disease. We study the ability of novel monoclonal antibodies, as well as antibodies taken from the plasma of healthy blood donors (IVIg) to inhibit disease progression in autoimmunity. We also study how an antibody called "anti-D" is able to prevent haemolytic disease of the fetus and newborn.

Assistant Professor

Research and education focus on transfusion medicine and benign hematology with a special interest in pediatric transfusion issues.  

Associate Professor

My research interests are in the appropriate use of blood transfusion and improving physician education in transfusion medicine.     

Assistant Professor
Professor

We investigate the role(s) of adhesion molecules (in particular the beta3 integrin & GPIb alpha complexes) involved in clot formation & their implications for hemostasis (incl. bleeding disorders) & thrombotic diseases (ie heart attack & stroke). We study allo- & autoimmune diseases related to bleeding disorders such as immune thrombocytopenia (ITP) & fetal & neonatal alloimmune thrombocytopenic purpura (FNAIT).

Associate Professor

My research interests include transfusion medicine (blood utilization, complications), TTP/HUS, therapeutic apheresis and patient blood management.

Assistant Professor

Physician practice patterns in transfusion medicine, transfusion support of hemoglobinopathies, safety and efficacy of blood components and fractionated plasma products, transfusion practice in rural and underserviced communities. 

Professor

Transfusion/platelet immunology, pathophysiology of immune thrombocytopenias, mechanism of action of IVIg/anti-D, transfusion-related acute lung injury (TRALI)

Associate Professor

My research interests are in transfusion medicine as it relates to cardiovascular surgery and maternal fetal medicine, hematological disorders disorders of pregnancy and evidence based practise guidelines.

Professor Emeritus / Emerita

Dr Shek's research addresses severe hemorrhage associated with coagulopathy that requires immediate blood loss control and fluid resuscitation. His other research area explores the application of magnetoencephalography for the objective diagnosis and assessment of post traumatic stress disorder (PTSD) and mild traumatic brain injury.

Assistant Professor

Dr. Sholzberg combines her clinical, laboratory and clinical epidemiology knowledge to uniquely address her research area of focus. Dr. Sholzberg's research interests include inherited and acquired disorders of hemostasis. Currently, she is involved in the study of: prediction tools for perioperative bleeding, the appropriateness of coagulation testing and new treatments for immune thrombocytopenia.

Associate Professor

Research interests:

  • Minimal residual disease in acute myeloid and lymphoblastic leukemia (AML-MRD coordinator for NOPHO)
  • Molecular biology of myeloid leukemia
  • Monoclonal B- lymphocytosis and B-cell lymphoma
Associate Professor
Lecturer

Areas of Special Interest:  Routine hematology, Coagulation, Hemoglobinopathies, and Diagnostics in Benign and Neoplastic Hematopathology, including Morphology and Flow Cytometry

Assistant Professor

My research interests include molecular biomarker studies involving hematopoietic neoplasms and solid tumors.  I am also interested in the applications of computational pathology for the field of hematopathology.

Assistant Professor

My research interests are molecular mechanisms of hematopoietic neoplasms.