Michal Opas
MSc, PhD
Contact information
Laboratory Medicine & Pathobiology
University of Toronto
1 King's College Circle, Rm 6326
M5S 1A8
Phone: 416-971-2140
Fax: 416-978-5959
Research location: University of Toronto - St. George Campus (downtown)
Primary Research Area: Molecular & Cell Biology
Secondary Research Area: Cardiovascular
Research Statement:

We study the role of calreticulin, a ubiquitous calcium-binding chaperone of the ER/SR, which affects calcium homeostasis and gene expression, in ES cell choice of fate.  We discovered that calreticulin acts as a switch either promoting (bone) or suppressing (fat) stem cell differentiation, while it seems to deregulate cardiogenesis.