Faculty Research Database

Molecular and cellular biology of lipoprotein metabolism in insulin-resistant states such as obesity and diabetes, and the link with cardiovascular disease.

My work is centered around transplant immunology and recurrent infections post-transplant.

Current research interest is in molecular biology and cytogentics of skin malignancies particularly melanoma and the implementation of molecular testing for diagnostic and targeted therapeutic purposes as part of personalized medicine.

Other areas of research include evaluation and implementation of whole slide imaging (WSI) as a tool for teledermatopathology     

Dr. Aldape is a neuropathologist with a research interest in primary brain tumors.  He has experience with identification of biomarkers in gliomas, including microarray studies.  He has identified a mesenchymal subgroup of glioma, which may be related to microenvironmental factors.  His work characterizes glioma subtypes as well as identifies clinically relevant molecular alterations in these tumors.

We study how processes important in normal development are recapitulated in repair processes or dysregulated in pathologic processes involving the musculoskeletal system. We are unraveling the role of signaling pathways such as Wnt and hedgehog, in stem cells, during embryonic development, in tissue repair and regeneration, as well as in neoplasia.

Our lab focuses on skin stem cells and using them for skin regeneration studies.  We employ in vitro and in vivo approaches to enlighten the process of wound healing post injury, identify and track the fate of cell(s) that contribute to the healing.  In collaboration with burn surgeon-scientists and chemical engineering scientists, we aim to create a “skin substitute” that can be used for burn patients.

My laboratory conducts multi-disciplinary studies to identify genetic alterations that play a role in breast cancer and sarcoma and to determine their clinical importance. Our goals are to explore the biology of these genetic alterations, to aid in diagnosis and treatment, and to discover novel targets for therapeutics.

Dr Asa is a Clinician-Scientist with a focus on Endocrine Pathology.  Her research aims to identify the basis for development of endocrine tumors, to improve diagnostic tests and to identify targets for novel therapies of those diseases.  

My research program is focused on translational genomics - specifically discovery and functional characterization of cancer biomarkers and their applications to clinical setting. A major area of current research is investigation of epigenetic markers of genitor-urinary and gastro-intestinal neoplasms using genome-wide interrogation strategies.           

Dr. Bartlett is Director of OICR’s Transformative Pathology Platform. He is developing new diagnostic approaches to improve patient diagnosis and treatment. By gaining an understanding of the molecular complexity of cancer, accurate diagnostic approaches can be developed to ensure that patients receive the most appropriate treatment.

I run a cardiovascular biology lab investigating molecular and cellular mechanisms of atherosclerosis and fibrotic heart disease.