Recent LMP Graduate News and Publications

Recent Graduate News
Recent Graduate Publications

Recent Graduate News

July 28, 2014
Developmental Cell: LMP researchers offer hope for people with incurable neurodegenerative diseases
Currently, patients with Amyotrophic Lateral Sclerosis (ALS) or Spinalcerebellar Ataxia type 2 (SCA2) have few options. These incurable neurodegenerative diseases affect a patient’s neurons, confine them to wheelchairs and greatly shorten their lifespan. Remarkably, researchers from U of T’s Department of Laboratory Medicine and Pathobiology (LMP) have defined potential treatment targets for these devastating diseases.

July 14, 2014
Maurice Pasternak wins 2014 Women's Health Scholars Award
Congratulations to MSc student Maurice Pasternak for winning a prestigious 2014 Women’s Health Scholars Award.  Funded by the Ontario Ministry of Health and Long-Term Care, these awards were established to promote research that will improve women’s health.

This year, six awards were given out across Ontario and Pasternak won one of only two MSc awards.

July 3, 2014
LMP students win at CIHR National Student Research Poster Competition
Congratulations to our students who participated in this year’s 2014 Canadian Institutes of Health Research (CIHR) National Student Research Poster Competition. This competition, recently held at the University of Manitoba, Winnipeg, involved over 450 graduate students with 121 students competing in the Poster Competition.

June 25, 2014
Stephen McCarthy spearheads Ally Blood Donor clinics during World Pride
Inspired by an act of love and support from his father, McCarthy worked with Canadian Blood Services, and the lesbian, gay, bisexual, transgender, two-spirit and Queer (LBGTTQ) community, to create Ally Blood Donor clinics to encourage individuals to donate in place of those who are ineligible.

May 29, 2014
LMP alumnus Stephen Mack wins Governor General’s Gold Medal
The Department of Laboratory Medicine and Pathobiology (LMP) would like to congratulate alumnus Stephen Mack (PhD) on receiving the Governor General’s Gold Medal. The Gold Medal is presented to three U of T graduate students who achieve the highest academic standing.

May 20, 2014
LMP students win first and second at HSRLCE Annual Cardiovascular Scientific Day
The Department of Laboratory Medicine and Pathobiology (LMP) is proud to announce that MSc candidate Xiaohong (Ruby) Xu and PhD candidate Yiming Wang received first and second prize respectively at the Heart and Stroke / Richard Lewar Centre of Excellence Annual Cardiovascular Scientific Day. Hosted at the Toronto Reference Library on Thursday, May 8, 2014, the competition was fierce with over 50 other poster presentations.

April 6, 2014
Nature Genetics: LMP researchers offer hope for children with previously incurable brain cancer
LMP Professor Cynthia Hawkins, a Scientist and Neuropathologist at The Hospital for Sick Children, along with PhD candidates Pawel Buczkowicz and Patricia Rakopoulos, have identified three subgroups of Diffuse Intrinsic Pontine Glioma, each having distinct molecular features.

March 31, 2014
Successful graduate students win awards from CGS Master’s Program
This year, 10 LMP students won awards from the Canada Graduate Scholarships – Master’s Program (CGS M). These awards include NSERC's Alexander Graham Bell Canada Graduate Scholarship and the CIHR's Frederick Banting and Charles Best Canada Graduate Scholarship.

March 18, 2014
Successful Graduate Research Conference 2014
Over 200 LMP students participated in the interactive and inspiring LMP Graduate Research Conference. The day featured 97poster presentations, a career planning session, symposia and keynote speaker Dr. Tak Mak.

February 18, 2014
Nature: LMP researchers discover new way to treat deadly childhood brain cancer
LMP Professor Michael Taylor, along with lead author Stephen Mack, reveal that epigenetics is the main cause of ependymoma. Remarkably, they have also identified FDA-approved drugs that could be used to treat this deadly childhood cancer.

January 10, 2014
Nature Medicine: Novel therapy decreases colorectal tumour growth by targeting self-renewing stem cells
LMP Professor Catherine O’Brien, along with co-principal investigator Prof. John Dick (PhD) and Antonija Kreso (PhD) from the Department of Molecular Genetics at the University of Toronto, demonstrated that a specific small molecule inhibitor of BMI-1 could effectively shrink colorectal tumours.

November 26, 2013
Lancet Oncology: Revealing the mystery behind recurrent medulloblastoma
Why is recurrent medulloblastoma, one of the most common childhood brain tumours, so fatal and is there potential to improve patient outcomes? In The Lancet Oncology, October 2013, researchers from LMP revealed that targeted therapy for recurrent medulloblastoma could be highly beneficial.

September 23, 2013
PhD candidate Sean McCurdy wins Vanier Canada Graduate Scholarship
PhD candidate Sean McCurdy wins the Canadian Institutes of Health Research (CIHR) Vanier Canada Graduate Scholarship. Valued at $150,000 over three years, McCurdy is one of 16 University of Toronto students to receive one of Canada’s most prestigious graduate awards.


Recent Graduate Publications

Our research-intensive atmosphere results in high-impact publications such as Nature, Nature Cell Biology, Nature Genetics, Nature Medicine, Cancer Cell, Journal of Clinical Oncology, Developmental Cell and the Journal of Clinical Investigation.

Lancet Oncology - May 2015
Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.
Torchia, J et al.

Journal of Clinical Investigation - October 2014
Plasma fibronectin supports hemostasis and regulates thrombosis.
Wang Y et al.

Developmental Cell - July 2014
Roles for Pbp1 and caloric restriction in genome and lifespan maintenance via suppression of RNA-DNA hybrids.
Salvi JS et al.

Nature Genetics - April 2014
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
Buczkowicz P et al.

Nature - February 2014
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
Mack SC et al.

Journal of Clinical Oncology - February 2014
Cytogenetic prognostication within medulloblastoma subgroups.
Shih DJ et al.

Blood - January 2014
Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis.
Douda DN et al.

Nature Communications - January 2014
The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs.
Rutnam ZJ et al.

Lancet Oncology - November 2013
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
Ramaswamy V et al.

Journal of Clinical Oncology August 2013
MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma.
Goswami RS et al.

Journal of Clinical Oncology - August 2013
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
Ramaswamy V et al.

EMBO Molecular Medicine - July 2013
MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways.
Cheng HS et al.

Cell Host Microbe - February 2013
Complement activation and the resulting placental vascular insufficiency  drives fetal growth restriction associated with placental malaria.
Conroy AL et al.

Nature - August 2012
Subgroupspecific structural variation across 1,000 medulloblastoma genomes.
Northcott PA et al.

Lancet Oncology - August 2012
Markers of survival and metastatic potential in childhood CNS primitive neuroectodermal brain tumours: an integrative genomic analysis.
Picard D et al.

Proceedings of the National Academy of Sciences - April 2012
Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERα- breast cancer.
Liu JC et al.

Journal of Cell Biology - April 2012
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion.
Rullo J et al.

Journal of Clinical Investigation - November 2011
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.
Li C, Piran S, et al.

Cancer Cell - August 2011
Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma.
Mack SC et al.

Developmental Cell - June 2011
Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains.
Poon BP et al.

Nature Medicine - June 2011
Identification of an innate T helper type 17 response to intestinal bacterial pathogens.
Rubino SJ et al.

Nature Medicine - June 2011
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
Russell RC et al.

Journal of Clinical Investigation - May 2011
Dual elimination of the glucagon and GLP1 receptors in mice reveals plasticity in the incretin axis.
Ali S et al.